2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141242
    Hydroxy-PEG4-C2-methyl ester 2228857-35-8
    Hydroxy-PEG4-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-C2-methyl ester
  • HY-140709
    m-PEG20000-thiol
    m-PEG20000-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG20000-thiol
  • HY-140799
    Azide-PEG8-alcohol 352439-36-2
    Azide-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG8-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG8-alcohol
  • HY-130715
    tert-Butyl 11-aminoundecanoate 220851-29-6 99.02%
    tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    tert-Butyl 11-aminoundecanoate
  • HY-128803
    Tos-PEG4-NH-Boc 1246999-33-6 ≥98.0%
    Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tos-PEG4-NH-Boc
  • HY-141360
    (2-Pyridyldithio)-PEG4-propargyl 2170240-99-8 98.47%
    (2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2-Pyridyldithio)-PEG4-propargyl
  • HY-132078
    Azido-PEG7-acid
    Azido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-acid
  • HY-140226
    m-PEG10-amine 1383658-09-0 99.97%
    m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG10-amine
  • HY-141388
    Bromoacetamido-PEG3-C2-Boc 1807537-33-2
    Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG3-C2-Boc
  • HY-140666
    Azide-PEG10000-azide
    Azide-PEG10000-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG10000-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG10000-azide
  • HY-130142A
    Biotinyl-NH-PEG3-C3-amido-C3-COOH 1202761-21-4 99.25%
    Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotinyl-NH-PEG3-C3-amido-C3-COOH
  • HY-130200
    NH2-PEG8-OH 352439-37-3
    NH2-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-OH
  • HY-113336B
    (±)15-HETE 71030-36-9 99.1%
    (±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (±)15-HETE
  • HY-42617
    Hydroxy-PEG4-CH2-Boc 169751-72-8
    Hydroxy-PEG4-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-CH2-Boc
  • HY-138396
    Rhodamine B PEG2-NH2
    Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Rhodamine B PEG2-NH2
  • HY-140008
    DOTA-PEG5-amine 98.0%
    DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DOTA-PEG5-amine
  • HY-138756
    PC DBCO-PEG4-NHS ester 2055025-02-8
    PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    PC DBCO-PEG4-NHS ester
  • HY-141238
    HO-PEG24-OH 2243942-52-9 99.89%
    HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG24-OH
  • HY-141208
    Hydroxy-PEG1-CH2-Boc 287174-32-7 99.49%
    Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG1-CH2-Boc
  • HY-122696
    CH2COOH-PEG3-CH2COOH 32775-08-9 99.06%
    CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    CH2COOH-PEG3-CH2COOH
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.